Nakamura S
Second Department of Internal Medicine, School of Medicine, Toho University, Tokyo, Japan.
Nihon Jinzo Gakkai Shi. 1993 Apr;35(4):343-7.
Relatively few studies have evaluated the chronic effects of atrial natriuretic polypeptide (ANP) administration into the central nervous system on peripheral cardiovascular and renal function under conditions of expanded extracellular fluid volume. The present investigation examined the effects of synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) chronically infused into the cerebroventriculum of rats loaded with 0.9% saline. Measurements of the arterial blood pressure, water and electrolyte balances were carried out during a 4-day central ventricular infusion of alpha-hANP. Significant increases in daily urine volume and urinary sodium and chloride excretion were observed, but no changes of arterial blood pressure occurred. These results indicate that elevated levels of ANP in the CSF can influence sodium and water excretion, but do not appear to influence arterial pressure.
相对较少的研究评估了在细胞外液量增加的情况下，将心房利钠多肽（ANP）注入中枢神经系统对周围心血管和肾功能的慢性影响。本研究检测了向输注0.9%盐水的大鼠脑室内长期输注合成α-人心房利钠多肽（α-hANP）的影响。在对α-hANP进行为期4天的脑室输注期间，测量了动脉血压、水和电解质平衡。观察到每日尿量以及尿钠和氯排泄量显著增加，但动脉血压没有变化。这些结果表明，脑脊液中升高的ANP水平可影响钠和水的排泄，但似乎不影响动脉血压。
