对正常血压和高血压自由活动大鼠脑室内注射合成的人及大鼠心房利钠肽的比较。

A comparison of synthetic human and rat ANP administered intracerebroventricularly in freely moving normotensive and hypertensive rats.

作者信息

Squadrito F, Frisina N, Buemi M, Sturniolo R, Autolitano A, Magri V, Squadrito G, Caputi A P

机构信息

Institute of Pharmacology, School of Medicine, University of Messina, Italy.

出版信息

J Cardiovasc Pharmacol. 1989;13 Suppl 6:S27-30.

PMID:2473344

Abstract

The effects of intracerebroventricular (i.c.v.) injection of alpha-human atrial natriuretic peptide (alpha-hANP) and alpha-rat atrial natriuretic peptide (alpha-rANP) were studied in normotensive [Wistar-Kyoto (WKY)] and spontaneously hypertensive rats (SHR). Intracerebroventricular injection of alpha-hANP (200, 400, and 800 ng in 5 microliters) did not modify mean arterial pressure (MAP), heart rate (HR), and water intake in both WKY rats and SHR. On the contrary, alpha-rANP (200, 400, and 800 ng in 5 microliters) caused strong dipsogenic, pressor, and bradycardic effects that were greater in hypertensive than in normotensive rats. Saralasin (9 microns in 5 microliters), injected 2 min prior to alpha-rANP, abated these effects, thus indicating an involvement of brain angiotensin. Our results suggest that, at least as far as the cerebral effects of ANP are concerned, some difference exists between alpha-rANP and human atrial natriuretic peptide.

摘要

研究了向正常血压的[Wistar-Kyoto（WKY）]大鼠和自发性高血压大鼠（SHR）脑室内（i.c.v.）注射α-人心房利钠肽（α-hANP）和α-大鼠心房利钠肽（α-rANP）的作用。向WKY大鼠和SHR脑室内注射α-hANP（5微升中含200、400和800纳克）不会改变平均动脉压（MAP）、心率（HR）和水摄入量。相反，α-rANP（5微升中含200、400和800纳克）会引起强烈的致渴、升压和心动过缓效应，高血压大鼠中的这些效应比正常血压大鼠中的更明显。在注射α-rANP前2分钟注射沙拉新（5微升中含9微克）可减轻这些效应，从而表明脑内血管紧张素参与其中。我们的结果表明，至少就ANP的脑效应而言，α-rANP和人心房利钠肽之间存在一些差异。