Harrison J E, McNeill K G, Meema H E, Oreopoulos D, Rabinovich S, Fenton S, Wilson D R
Metabolism. 1977 Mar;26(3):255-65. doi: 10.1016/0026-0495(77)90072-5.
The bone calcium status of 39 patients with chronic renal failure on hemodialysis has been measured by in vivo neutron activation analysis (IVNAA) and reported in terms of a calcium bone index (CaBl) which relates the calcium in a patient to that in a normal person of the same height. In 20 of the 39 cases sequential measurements were made over periods of up to 40 mo. The results are compared with data obtained by radiology and by histological examination of bone biopsies. CaBl values varied from below normal to, in one case, above the range of normal. Many of the higher values were associated with demonstrable osteosclerosis. As found in previous work here with IVNAA, significantly low values of CaBl were associated with vertebral deformities; however, some patients with deformity had normal CaBl values, indicating that these had both local mineral loss (resulting in fracture) and osteosclerosis. Taken all together, the data suggest that more than half the patients have osteosclerosis. Sequential data showed no uniform response to treatment.
采用体内中子活化分析（IVNAA）测定了39例慢性肾功能衰竭血液透析患者的骨钙状况，并以钙骨指数（CaBl）报告，该指数将患者体内的钙与相同身高正常人的钙进行了关联。39例中有20例在长达40个月的时间内进行了连续测量。将结果与通过放射学和骨活检组织学检查获得的数据进行了比较。CaBl值从低于正常到有1例高于正常范围不等。许多较高的值与可证实的骨硬化有关。正如此前在此处使用IVNAA所发现的，CaBl值显著偏低与椎体畸形有关；然而，一些有畸形的患者CaBl值正常，这表明这些患者既有局部矿物质流失（导致骨折）又有骨硬化。综合来看，数据表明超过一半的患者有骨硬化。连续数据显示对治疗没有一致的反应。
