Chen C W
U.S. Environmental Protection Agency, Washington, D.C. 20460.
Risk Anal. 1993 Jun;13(3):273-9. doi: 10.1111/j.1539-6924.1993.tb01079.x.
The objective of this paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis (a model proposed by Moolgavkar and colleagues) by revealing the relationship between the Armitage-Doll two-stage model and the simplified MVK model; and (2) to extend the Armitage-Doll two-stage model to one with time-varying (piece-wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage-Doll two-stage model, and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the Armitage-Doll two-stage model with piece-wise constant parameters. The limitations of the Armitage-Doll two-stage model are discussed.
(1) 通过揭示阿米蒂奇-多尔两阶段模型与简化的MVK模型之间的关系，深入了解简化的MVK致癌模型（由穆尔加夫卡尔及其同事提出的模型）；(2) 将阿米蒂奇-多尔两阶段模型扩展为具有时变（分段常数）参数的模型。结果表明，简化的MVK模型是阿米蒂奇-多尔两阶段模型的一个特例，并且许多涉及间歇性暴露或在不同时间段暴露于不同化合物的简化MVK模型的应用都可以很容易地从具有分段常数参数的阿米蒂奇-多尔两阶段模型中推导出来。文中还讨论了阿米蒂奇-多尔两阶段模型的局限性。
