红霉素、胃动素与食管

Erythromycin, motilin, and the esophagus.

作者信息

Pennathur A, Cioppi M, Fayad J B, Little A G

机构信息

Department of Surgery, University of Nevada School of Medicine, Las Vegas.

出版信息

Surgery. 1993 Aug;114(2):295-8; discussion 298-9.

PMID:8342132

Abstract

BACKGROUND

Motilin induces phase III activity of the gastroesophageal tract. Erythromycin has a motilin-like effect on the stomach, but possible esophageal effects have not been evaluated and are the focus of our investigation.

METHODS

Esophageal manometry was performed in 11 healthy volunteers before and after intravenous infusion of 500 mg erythromycin. Values are expressed as means +/- SEM.

RESULTS

Lower esophageal sphincter (LES) pressure increased from 21.1 +/- 2.6 mm Hg at baseline to 37.5 +/- 3.8 mm Hg after erythromycin infusion (p < 0.0001). Erythromycin did not affect LES length, esophageal body contraction amplitude, duration or velocity, or the upper esophageal sphincter. Serum motilin levels decreased from 96.4 +/- 10.9 pmol/L to 81.8 +/- 10.9 pmol/L (p < 0.01) after erythromycin administration.

CONCLUSIONS

Erythromycin profoundly stimulates the normal human LES. This is a direct motilin agonist-like effect and is not mediated by release of endogenous motilin. Erythromycin has no important effect on the esophageal body or the upper esophageal sphincter.

摘要

背景

胃动素可诱导胃肠道的Ⅲ期活动。红霉素对胃有类似胃动素的作用，但对食管的可能影响尚未评估，这是我们研究的重点。

方法

对11名健康志愿者在静脉输注500mg红霉素前后进行食管测压。数值以平均值±标准误表示。

结果

静脉输注红霉素后，食管下括约肌（LES）压力从基线时的21.1±2.6mmHg升高至37.5±3.8mmHg（p<0.0001）。红霉素不影响LES长度、食管体收缩幅度、持续时间或速度，也不影响食管上括约肌。给予红霉素后，血清胃动素水平从96.4±10.9pmol/L降至81.8±10.9pmol/L（p<0.01）。