Gutzow I, Atanassova S, Budevsky G, Neykov K
Institute of Physical Chemistry, Bulgarian Academy of Sciences, Sofia.
Urol Res. 1993 May;21(3):181-5. doi: 10.1007/BF00590034.
An analysis of crystal growth and dissolution of slightly soluble salts in physiological solutions in the presence of complexing ions was carried out, simulating conditions typical in human urine. It was found that hippuric acid, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to calcium oxalate (CaOx) and CaOx calculi. The kinetics of dissolution of crystalline CaOx calculi in physiological solutions containing hippuric acid at different concentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. Analysis of the experimental results enabled the determination of the increased solubility of CaOx in the presence of hippuric acid and the quantitative characterization of this substance as a new and promising agent for dissolving CaOx calculi in human urine. The possible effect of hippuric acid as a natural regulator of CaOx supersaturation and crystallization in human and mammalian urine is also discussed.
在存在络合离子的情况下，对微溶性盐在生理溶液中的晶体生长和溶解进行了分析，模拟了人类尿液中的典型条件。研究发现，马尿酸作为尿液的一种正常生理成分，在浓度升高时对草酸钙（CaOx）和CaOx结石起溶解剂的作用。利用浸泡在溶液中的样品阿基米德重量的变化，研究了结晶CaOx结石在含有不同浓度马尿酸的生理溶液中的溶解动力学。对实验结果的分析能够确定在马尿酸存在下CaOx溶解度的增加，并将该物质定量表征为一种溶解人类尿液中CaOx结石的新型且有前景的试剂。还讨论了马尿酸作为人类和哺乳动物尿液中CaOx过饱和度和结晶的天然调节剂的可能作用。
