Department of Clinical Laboratory and Clinical Immunology, Medical University, "G. Sofiisky" Boulevard 1, 1431 Sofia, Bulgaria.
Biomed Res Int. 2013;2013:374950. doi: 10.1155/2013/374950. Epub 2013 Nov 7.
At present, the clinical significance of existing physicochemical and biological evidence and especially the results we have obtained from our previous in vitro experiments have been analyzed, and we have come to the conclusion that hippuric acid (C6H5CONHCH2COOH) is a very active solvent of Calcium Oxalate (CaOX) in physiological solutions. Two types of experiments have been discussed: clinical laboratory analysis on the urine excretion of hippuric acid (HA) in patients with CaOX lithiasis and detailed measurements of the kinetics of the dissolution of CaOX calculi in artificial urine, containing various concentrations of HA. It turns out that the most probable value of the HA concentration in the control group is approximately ten times higher than the corresponding value in the group of the stone-formers. Our in vitro analytical measurements demonstrate even a possibility to dissolve CaOX stones in human urine, in which increased concentration of HA have been established. A conclusion can be that drowning out HA is a significant regulator of CaOX supersaturation and thus a regulation of CaOX stone formation in human urine. Discussions have arisen to use increased concentration of HA in urine both as a solubilizator of CaOX stones in the urinary tract and on the purpose of a prolonged metaphylactic treatment.
目前，我们分析了现有物理化学和生物学证据的临床意义，特别是我们以前在体外实验中获得的结果，得出结论：马尿酸（C6H5CONHCH2COOH）是生理溶液中草酸钙（CaOX）非常活跃的溶剂。讨论了两种类型的实验：对草酸钙结石患者尿液中马尿酸（HA）排泄的临床实验室分析，以及对含有各种浓度 HA 的人工尿液中 CaOX 结石溶解动力学的详细测量。事实证明，对照组中 HA 的最可能浓度值大约是结石形成组相应值的十倍。我们的体外分析测量甚至表明有可能在已确定 HA 浓度增加的人尿中溶解 CaOX 结石。可以得出这样的结论：抑制 HA 是调节 CaOX 过饱和度的重要调节剂，从而调节人尿中 CaOX 结石的形成。有人提出，增加尿液中的 HA 浓度，既可以作为尿路中 CaOX 结石的溶解剂，也可以作为长期预防治疗的目的。
