Glathe H, Bigl S, Grosche A
Robert Koch-Institute, Department Schöneweide, Federal Health Office, Berlin, Germany.
Vaccine. 1993;11(7):702-5. doi: 10.1016/0264-410x(93)90252-s.
A total of 296 volunteers in five different groups were immunized with one dose of the commercial 1991-1992 trivalent split influenza vaccine formulation A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2) and B/Yamagata/16/88. The groups differed in age (young adults, middle-aged and elderly) and history of previous vaccination. Antibodies were determined in pre- and postvaccination sera by haemagglutination inhibition assay and the results were evaluated as geometric mean titre, mean fold antibody increase, protection and response rates. No significant age-related differences among the protection rates were found. The proportion of vaccinees with antibodies > or = 40 ranged between 70 and 95%. Compared with the H3N2 and B components the antibody response to the H1N1-component was low. Residents of a nursing home fully vaccinated the previous year developed 7.6-8.4-fold antibody increases and showed 96-100% protection rates.
共有来自五个不同组别的296名志愿者接种了一剂市售的1991 - 1992年三价裂解流感疫苗，其毒株为A/新加坡/6/86（H1N1）、A/北京/353/89（H3N2）和B/山形/16/88。这些组在年龄（年轻人、中年人和老年人）以及既往接种史方面存在差异。通过血凝抑制试验测定接种前和接种后血清中的抗体，并将结果评估为几何平均滴度、抗体平均增长倍数、保护率和应答率。未发现保护率之间存在显著的年龄相关差异。抗体≥40的接种者比例在70%至95%之间。与H3N2和B组分相比，对H1N1组分的抗体应答较低。前一年完全接种疫苗的养老院居民抗体增长了7.6至8.4倍，保护率为96%至100%。
