McKeigue P M, Laws A, Chen Y D, Marmot M G, Reaven G M
Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK.
Arterioscler Thromb. 1993 Aug;13(8):1187-92. doi: 10.1161/01.atv.13.8.1187.
To test whether a sex difference in insulin-mediated suppression of nonesterified fatty acids (NEFAs) could account for sex differences in plasma triglyceride levels, we studied 632 normoglycemic men and women of European and South Asian descent aged 40 to 69 years. Mean fasting NEFA levels were 19% higher in women than in men. Between fasting and 2 hours after a 75-g oral glucose load, NEFA levels fell by 69% in women and 55% in men, so that mean NEFA levels at 2 hours after loading were 19% lower in women than in men. Plasma triglyceride and apolipoprotein B levels were correlated with 2-hour NEFA levels in each sex and ethnic group, and these associations were independent of glucose, insulin, and central obesity. These results are consistent with experimental studies of the effects of insulin and NEFAs on hepatic production of triglycerides and apolipoprotein B. Suppression of NEFA levels in response to insulin is greater in women than in men, and this may account for some of the sex differences in lipoprotein pattern and coronary heart disease risk.
为了检验胰岛素介导的非酯化脂肪酸（NEFAs）抑制作用的性别差异是否能解释血浆甘油三酯水平的性别差异，我们研究了632名年龄在40至69岁之间、具有欧洲和南亚血统的血糖正常的男性和女性。女性的空腹NEFA平均水平比男性高19%。在口服75克葡萄糖负荷后，从空腹到2小时期间，女性的NEFA水平下降了69%，男性下降了55%，因此负荷后2小时女性的NEFA平均水平比男性低19%。在每个性别和种族群体中，血浆甘油三酯和载脂蛋白B水平与2小时NEFA水平相关，并且这些关联独立于血糖、胰岛素和中心性肥胖。这些结果与胰岛素和NEFAs对肝脏甘油三酯和载脂蛋白B产生影响的实验研究一致。女性对胰岛素反应的NEFA水平抑制作用比男性更大，这可能解释了脂蛋白模式和冠心病风险中的一些性别差异。
