Sumner A E, Kushner H, Lakota C A, Falkner B, Marsh J B
Medical College of Pennsylvania, Philadelphia, USA.
Lipids. 1996 Mar;31 Suppl:S275-8. doi: 10.1007/BF02637090.
This study of African Americans (AA) was designed to investigate gender differences in insulin-induced free fatty acid (FFA) suppression. Sixty AA (34 women, mean age 34 +/- 7.6 years, and 26 men, mean age 30 +/- 2.9 years) participated. All subjects had an oral glucose tolerance test (OGTT). Nineteen women and 18 men also underwent a euglycemic hyperinsulinemic clamp (IC) study. Plasma insulin and FFA concentrations were obtained during both tests at 0, 60, and 120 min. While there was no gender difference in body mass index (P = 0.21), women had greater percent body fat (P < 0.001) calculated by the Siri formula. There was no gender difference in fasting FFA levels, but during the OGTT, women compared to men had significantly greater FFA suppression. Both nonobese and obese women suppressed FFA concentration by 88%, and nonobese and obese men suppressed FFA concentration by 80 and 66% respectively. This gender difference in FFA suppression was significant (P = 0.001) and independent of obesity and insulin concentration. During the IC studies, there were no gender or obesity differences in FFA suppression, with women and men suppressing FFA levels by 87-89% (P = 0.7). Fasting insulin concentrations were higher in obese vs. nonobese (P = 0.03), but fasting FFA concentrations were not different (P = 0.15). For nonobese and obese females, fasting FFA levels were 0.55 +/- 0.24 and 0.44 +/- 0.26 mEq/L, respectively, and for nonobese and obese males, 0.45 +/- 0.2 and 0.35 +/- 0.18 mEq/L, respectively. In women, development of obesity may be enhanced by greater sensitivity to insulin-induced FFA suppression as measured during an OGTT. To detect gender differences in FFA metabolism, the OGTT is superior to the IC. The lack of elevation in fasting FFA levels in obese AA women and men has not been reported in other racial groups and may indicate a greater adipocyte sensitivity to insulin in AA.
这项针对非裔美国人（AA）的研究旨在调查胰岛素诱导的游离脂肪酸（FFA）抑制中的性别差异。60名非裔美国人参与了研究（34名女性，平均年龄34±7.6岁；26名男性，平均年龄30±2.9岁）。所有受试者均进行了口服葡萄糖耐量试验（OGTT）。19名女性和18名男性还接受了正常血糖高胰岛素钳夹（IC）研究。在两项试验的0、60和120分钟时获取血浆胰岛素和FFA浓度。虽然体重指数没有性别差异（P = 0.21），但根据Siri公式计算，女性的体脂百分比更高（P < 0.001）。空腹FFA水平没有性别差异，但在OGTT期间，与男性相比，女性的FFA抑制作用明显更强。非肥胖和肥胖女性的FFA浓度均抑制了88%，非肥胖和肥胖男性的FFA浓度分别抑制了80%和66%。FFA抑制方面的这种性别差异具有显著性（P = 0.001），且与肥胖和胰岛素浓度无关。在IC研究期间，FFA抑制没有性别或肥胖差异（P = 0.7），女性和男性的FFA水平均抑制了87 - 89%。肥胖者的空腹胰岛素浓度高于非肥胖者（P = 0.03），但空腹FFA浓度没有差异（P = 0.15）。对于非肥胖和肥胖女性，空腹FFA水平分别为0.55±0.24和0.44±0.26 mEq/L，对于非肥胖和肥胖男性，分别为0.45±0.2和0.35±0.18 mEq/L。在女性中，如在OGTT期间所测，对胰岛素诱导的FFA抑制的更高敏感性可能会增强肥胖的发展。为检测FFA代谢中的性别差异，OGTT优于IC。在其他种族群体中尚未报道非裔美国肥胖女性和男性空腹FFA水平未升高的情况，这可能表明非裔美国人的脂肪细胞对胰岛素更敏感。
