Petrek M, Kolek V
Institute of Immunology, Medical Faculty of the Palacký University, Olomouc, Czechoslovakia.
Acta Univ Palacki Olomuc Fac Med. 1991;130:169-77.
Bronchoalveolar T-lymphocyte subsets were evaluated in seven patients with pulmonary sarcoidosis and eight patients with other interstitial lung disorders. Both disease groups considerably differed in the distribution of bronchoalveolar CD4+ and CD8+ cells. The lymphocytic alveolitis in sarcoidosis was characterized by excess CD4+ (helper-inducer) cells; mean CD4/CD8 ratio was 6.8 +/- 3.8. Inversely, in the lungs of patients with other interstitial pulmonary disorders a less pronounced but clear predominance of CD8+ (suppressor-cytotoxic) lymphocytes was observed with CD4/CD8 ratio 0.7 +/- 0.4. The results of the study suggest that the determination of the major immunoregulatory subsets of bronchoalveolar lymphocytes contributes to the reliable differentiation of sarcoidosis from other interstitial lung disorders. The recent advances improving our understanding of the pathogenesis of sarcoidosis are briefly reviewed in the discussion.
对7例肺结节病患者和8例其他间质性肺疾病患者的支气管肺泡T淋巴细胞亚群进行了评估。两组疾病在支气管肺泡CD4+和CD8+细胞的分布上有显著差异。结节病中的淋巴细胞性肺泡炎以CD4+（辅助诱导）细胞过多为特征；平均CD4/CD8比值为6.8±3.8。相反，在其他间质性肺疾病患者的肺中，观察到CD8+（抑制-细胞毒性）淋巴细胞的优势不太明显但很明显，CD4/CD8比值为0.7±0.4。研究结果表明，测定支气管肺泡淋巴细胞的主要免疫调节亚群有助于将结节病与其他间质性肺疾病可靠地区分开来。讨论部分简要回顾了最近有助于我们更好地理解结节病发病机制的进展。
