Hunter D J, Julier D, Franklin M, Green E
Obstet Gynecol. 1977 Feb;49(2):180-5.
Plasma levels of luteinizing hormone, follicle stimulating hormone, and estrogen were studied serially in 20 patients before and after hysterectomy and bilateral salpingo-oophorectomy. Ten patients received an implant of estradiol-17 beta (100 mg) at the time of operation. Ten patients who did not receive an implant acted as controls. Patients recorded the severity of vasomotor symptoms before and after hysterectomy. In those patients who did not receive an implant, plasma estrogen levels fell from a mean preoperative level of 18.1 +/- 10.4 ng/100 ml to 8.7 +/- 1.4 ng/100 ml by 24 hours after oophorectomy and they remained in this range for the 6 months of the study. No significant change in the plasma estrogen level was noted after oophorectomy in those patients who received an implant. The implant prevented the rise in gonadotropin levels and the appearance of vasomotor symptoms seen in those patients who underwent oophorectomy without an implant. Insertion of an implant into oophorectomized patients caused the plasma estrogen level to return to premenopausal levels within 2 weeks and the gonadotropin levels to premenopausal values within 6 weeks. Hot flashes were alleviated within 2 to 6 days. The usefulness of this type of therapy in preventing the appearance of vasomotor symptoms at the time of oophorectomy in premenopausal patients is confirmed.
对20例患者在子宫切除及双侧输卵管卵巢切除术前、术后连续检测黄体生成素、卵泡刺激素和雌激素的血浆水平。10例患者在手术时植入了17β-雌二醇（100毫克）。10例未植入的患者作为对照。患者记录子宫切除术前、后的血管舒缩症状严重程度。在未植入的患者中，卵巢切除术后24小时，血浆雌激素水平从术前平均水平18.1±10.4纳克/100毫升降至8.7±1.4纳克/100毫升，在研究的六个月内一直保持在这个范围内。植入的患者在卵巢切除术后血浆雌激素水平无显著变化。植入物可防止接受卵巢切除术但未植入的患者出现促性腺激素水平升高和血管舒缩症状。对卵巢切除术后的患者植入可使血浆雌激素水平在2周内恢复到绝经前水平，促性腺激素水平在6周内恢复到绝经前值。潮热在2至6天内得到缓解。证实了这种治疗方法在预防绝经前患者卵巢切除时出现血管舒缩症状方面的有效性。
