Aksel S, Schomberg D W, Tyrey L, Hammond C B
Am J Obstet Gynecol. 1976 Sep 15;126(2):165-9. doi: 10.1016/0002-9378(76)90270-2.
Hormonal parameters of young women who developed vasomotor symptoms in the immediate postoperative period following castration are compared to those who remained asymptomatic. Only 37.5 per cent of 16 premenopausal women developed "hot flushes" after operation. Perimenopausal women with vasomotor symptoms and elevated follicle-stimulating hormone levels demonstrated normal luteinizing hormone and estrogen values preoperatively. There were no statistically significant differences in total serum estrogen, follicle-stimulating hormone, or luteinizing hormone concentrations between the group of patients with symptoms and the group withoyt symptoms. The results of the study indicate that rising gonadotropin or declining estrogen values appear to have no direct correlation to the onset of vasomotor symptoms in the immediate postoperative period. Thus, the precise etiology of the "hot flush" remains to be elucidated.
将接受阉割手术后短期内出现血管舒缩症状的年轻女性的激素参数，与未出现症状的女性进行比较。16名绝经前女性中只有37.5%在术后出现了“潮热”。有血管舒缩症状且促卵泡激素水平升高的围绝经期女性术前促黄体生成素和雌激素值正常。有症状患者组和无症状患者组之间的血清总雌激素、促卵泡激素或促黄体生成素浓度没有统计学上的显著差异。研究结果表明，促性腺激素升高或雌激素值下降似乎与术后短期内血管舒缩症状的发作没有直接关联。因此，“潮热”的确切病因仍有待阐明。
