Osterholzer H O, Grillo D, Kruger P S, Dunnihoo D R
Obstet Gynecol. 1977 Feb;49(2):227-32.
Uteri from 38 patients exposed to oral contraceptive steroids and from 7 unexposed controls were examined for lesions in small branches of the uterine artery. Moderate or severe cellular proliferation of the intimal layer was found in 82% of patients exposed to exogenous steroids, but minimal or no involvement was found in the remaining 18% and in unexposed patients. The severity of involvement correlated with duration of exposure to contraceptive steroids but decreased in those patients who had stopped medication prior to surgery. This lesion has been reported previously in autopsy studies of women receiving contraceptive steroids and dying from vascular disease, but is now shown to be common in asymptomatic women receiving oral contraceptive pills.
对38名服用口服避孕甾体激素的患者以及7名未服用的对照者的子宫进行检查，以观察子宫动脉小分支的病变情况。在外源性甾体激素使用者中，82%发现内膜层有中度或重度细胞增殖，其余18%以及未使用者仅有轻微病变或无病变。病变严重程度与接触避孕甾体激素的时间相关，但在手术前停药的患者中病变程度减轻。此前在接受避孕甾体激素且死于血管疾病的女性尸检研究中曾报告过这种病变，但现在发现它在服用口服避孕药的无症状女性中很常见。
