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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Division of Biochemical Pharmacology, Korea Ginseng and Tobacco Research Institute, Taejon.

Int J Biochem. 1993 Jun;25(6):911-5. doi: 10.1016/0020-711x(93)90247-c.

The effects of carotenes (alpha- and beta-) on edema, MDA contents and peroxidizability of croton oil-treated mouse skin epidermis, hydroperoxide production and enzymatic lipid peroxidation of epidermal homogenates were studied. Edema was determined as ear punch weight and the intensity of lipid peroxidation was measured using malondialdehyde formation. 2. Carotenes (alpha- and beta-) significantly suppressed edema formation, hydroperoxide production, lipid peroxidation caused by croton oil, Fe + 3-ADP/NADPH or paraquat/NADPH in vivo as well as in vitro. 3. These results indicate that both alpha- and beta-carotene have chemopreventive effects on croton oil-induced tumor promotion in skin tumorigenesis by scavenging oxygen free radicals, indirectly determined as carotene inhibition of lipid peroxidation and hydroperoxide formation.

研究了胡萝卜素（α-和β-）对巴豆油处理的小鼠皮肤表皮水肿、丙二醛含量及过氧化能力、表皮匀浆中氢过氧化物生成及酶促脂质过氧化的影响。水肿通过耳打孔重量测定，脂质过氧化强度通过丙二醛生成量来衡量。2. 胡萝卜素（α-和β-）在体内和体外均能显著抑制巴豆油、Fe + 3-ADP/NADPH或百草枯/NADPH引起的水肿形成、氢过氧化物生成及脂质过氧化。3. 这些结果表明，α-胡萝卜素和β-胡萝卜素在皮肤肿瘤发生过程中对巴豆油诱导的肿瘤促进均具有化学预防作用，其机制是通过清除氧自由基，这可间接通过胡萝卜素对脂质过氧化和氢过氧化物生成的抑制作用来确定。

Division of Biochemical Pharmacology, Korea Ginseng and Tobacco Research Institute, Taejon.

Int J Biochem. 1993 Jun;25(6):911-5. doi: 10.1016/0020-711x(93)90247-c.

The effects of carotenes (alpha- and beta-) on edema, MDA contents and peroxidizability of croton oil-treated mouse skin epidermis, hydroperoxide production and enzymatic lipid peroxidation of epidermal homogenates were studied. Edema was determined as ear punch weight and the intensity of lipid peroxidation was measured using malondialdehyde formation. 2. Carotenes (alpha- and beta-) significantly suppressed edema formation, hydroperoxide production, lipid peroxidation caused by croton oil, Fe + 3-ADP/NADPH or paraquat/NADPH in vivo as well as in vitro. 3. These results indicate that both alpha- and beta-carotene have chemopreventive effects on croton oil-induced tumor promotion in skin tumorigenesis by scavenging oxygen free radicals, indirectly determined as carotene inhibition of lipid peroxidation and hydroperoxide formation.

研究了胡萝卜素（α-和β-）对巴豆油处理的小鼠皮肤表皮水肿、丙二醛含量及过氧化能力、表皮匀浆中氢过氧化物生成及酶促脂质过氧化的影响。水肿通过耳打孔重量测定，脂质过氧化强度通过丙二醛生成量来衡量。2. 胡萝卜素（α-和β-）在体内和体外均能显著抑制巴豆油、Fe + 3-ADP/NADPH或百草枯/NADPH引起的水肿形成、氢过氧化物生成及脂质过氧化。3. 这些结果表明，α-胡萝卜素和β-胡萝卜素在皮肤肿瘤发生过程中对巴豆油诱导的肿瘤促进均具有化学预防作用，其机制是通过清除氧自由基，这可间接通过胡萝卜素对脂质过氧化和氢过氧化物生成的抑制作用来确定。