Bar-Hava I, Bronshtein M, Ornoy A, Ben-Rafael Z
Dept. of Obstetrics and Gynecology, Golda Meir Medical Center, Petah Tikva.
Harefuah. 1993 Jun 1;124(11):685-7, 739.
Anencephaly, a well-known lethal fetal malformation, was long considered to result from primary nonclosure of the neural tube. In the past few years other pathogenic mechanisms, such as reopening or degeneration of a closed neural tube have been suggested. High-resolution transvaginal ultrasonography, which provides fine visualization of the different stages in embryogenesis, allowed us to detect fetal acrania as early as the 12th week of gestation. Very high levels of alpha-fetoprotein, almost undetectable levels of unconjugated estriol (E3), and postabortion histology were consistent with anencephaly, suggesting that anencephaly is the end result of fetal acrania.
无脑儿是一种众所周知的致死性胎儿畸形，长期以来被认为是神经管原发性未闭合所致。在过去几年中，有人提出了其他致病机制，如已闭合的神经管重新开放或退化。高分辨率经阴道超声检查能够清晰显示胚胎发育的不同阶段，使我们早在妊娠第12周就能检测到胎儿无颅骨。甲胎蛋白水平极高、未结合雌三醇（E3）水平几乎检测不到以及流产后的组织学检查结果均与无脑儿相符，提示无脑儿是胎儿无颅骨的最终结果。
