Weissman A, Diukman R, Auslender R
Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.
J Clin Ultrasound. 1997 Nov-Dec;25(9):511-4. doi: 10.1002/(sici)1097-0096(199711/12)25:9<511::aid-jcu10>3.0.co;2-7.
Acrania is a lethal malformation in which there is an absence of the flat skull bones covering the brain. Five new cases are described, and a review of the English-language medical literature is presented. The sonographic differential diagnosis of acrania includes anencephaly, large cephalocele, osteogenesis imperfecta, and hypophosphatasia. The diagnosis of acrania can be established sonographically even in the first trimester if a large mass of disorganized brain tissue covered only by a thin membrane is detected.
无脑颅骨畸形是一种致命的畸形，即覆盖大脑的扁平颅骨缺失。本文描述了5例新病例，并对英文医学文献进行了综述。无脑颅骨畸形的超声鉴别诊断包括无脑儿、巨大脑膨出、成骨不全和低磷酸酯酶症。即使在孕早期，如果检测到仅被一层薄膜覆盖的大量杂乱脑组织，也可通过超声诊断无脑颅骨畸形。
