Dzuda C, Morton D J
Department of Pharmacy, University of Zimbabwe, Mount Pleasant, Harare.
J Clin Pharm Ther. 1993 Jun;18(3):187-90. doi: 10.1111/j.1365-2710.1993.tb00611.x.
The relationship between temperature and the degradation of reconstituted penicillin solutions was evaluated. In all cases storage at temperatures of 25 degrees C or less was sufficient to maintain penicillin stability within acceptable pharmacopoeial limits for 5 days. In addition, the relationship between humidity and dry bulb temperature was examined in order to assess the use of evaporative cooling in lowering the temperature of penicillin solutions in those areas of the country where temperatures commonly exceed 25 degrees C. The results of this study suggest that, with the use of evaporative cooling, penicillin solutions can be maintained in a stable state for a 5-day period without the need for refrigeration.
评估了温度与复溶青霉素溶液降解之间的关系。在所有情况下，在25摄氏度或更低温度下储存足以使青霉素在5天内保持在可接受的药典限度内的稳定性。此外，还研究了湿度与干球温度之间的关系，以评估在该国温度通常超过25摄氏度的地区使用蒸发冷却来降低青霉素溶液温度的情况。这项研究的结果表明，通过使用蒸发冷却，青霉素溶液无需冷藏即可在5天内保持稳定状态。
