Roth P, Maillet R, Dalphin M L, Schaal J P, Colette C
Clinique Universitaire de Gynécologie, d'Obstétrique et de la Reproduction, CHRU Besançon.
J Gynecol Obstet Biol Reprod (Paris). 1993;22(3):277-83.
About 1% of all pregnancies in France are complicated by a primary infection with toxoplasmosis. The risk for the fetus being affected increases during the pregnancy but the seriousness of the effect on the fetus becomes less with more advanced pregnancies. Treatment of the mother using Spiramycin have been proven to be efficient, lessening the risk for the fetus being affected. The diagnosis of the fetus being affected rests on a whole bundle of presumptive evidence culled from non-invasive methods and invasive methods which are not without risk. (Direct or over-enthusiastic diagnostic techniques or none at all). We have studied a series of 101 primary infections with toxoplasmosis for which we have not carried out any invasive diagnostic techniques. The long term results in 77 infants show no difference in fetal morbidity and better results as far as mortality are concerned. We therefore propose simplifying the diagnostic approach in cases of primary infection with toxoplasmosis during pregnancy.
在法国,约1%的妊娠会因初次感染弓形虫而变得复杂。胎儿受感染的风险在孕期会增加,但随着孕周增加,对胎儿影响的严重程度会降低。已证实使用螺旋霉素治疗母亲是有效的,可降低胎儿受感染的风险。胎儿是否受感染的诊断基于一系列从非侵入性方法和有风险的侵入性方法中筛选出的推定证据。(直接或过度积极的诊断技术,或根本没有诊断技术)。我们研究了101例初次感染弓形虫的病例,对于这些病例我们未进行任何侵入性诊断技术。77名婴儿的长期结果显示,胎儿发病率没有差异,而就死亡率而言结果更好。因此,我们建议简化孕期初次感染弓形虫病例的诊断方法。