Carlyle W, Ancill R J, Sheldon L
Department of Psychiatry, St. Vincent's Hospital, Vancouver, BC, Canada.
Int Clin Psychopharmacol. 1993 Summer;8(2):103-8. doi: 10.1097/00004850-199300820-00004.
Aggression is common in dementia, with devastating social consequences. While high or low potency neuroleptics are the usual treatment of choice, they have been shown to yield inconsistent behavioral improvement and significant iatrogenic disability. This double-blind study was undertaken with aggressive demented patients to assess the efficacy and safety of a mid-potency neuroleptic, loxapine, in comparison to the more commonly prescribed high potency drug, haloperidol. Using an optimizing dosage regime, the outcome variables studied were aggression frequency and the number and nature of emergent side effects. Results demonstrated no significant difference regarding efficacy, but significantly fewer side effects with loxapine administration. The clinical and theoretical implications of these findings are discussed.
攻击行为在痴呆症中很常见，会带来严重的社会后果。虽然高效或低效神经安定剂是常用的治疗选择，但已证明它们在改善行为方面效果不一，且会导致严重的医源性残疾。本双盲研究针对有攻击行为的痴呆患者，旨在评估中效神经安定剂洛沙平与更常用的高效药物氟哌啶醇相比的疗效和安全性。采用优化剂量方案，研究的结果变量为攻击频率以及出现的副作用的数量和性质。结果表明，在疗效方面没有显著差异，但服用洛沙平产生的副作用明显较少。本文讨论了这些发现的临床和理论意义。
