Milton C M, Shotton J C, Premachandran D J, Woodward B M, Fabre J W, Sergeant R J
Department of Otolaryngology, Kent and Sussex Hospital, Tunbridge Wells.
J Laryngol Otol. 1993 Jun;107(6):510-3. doi: 10.1017/s0022215100123588.
A new technique for the treatment of severe epistaxis associated with hereditary haemorrhagic telangiectasia is described. The nasal septum and inferior turbinates, surgically denuded of respiratory epithelium, were grafted using autografts of cultured epithelial sheets derived from buccal epithelium. All patients upon whom this technique has been used have shown considerable lessening in the frequency and severity of their epistaxes although two patients received grafts on two occasions, in each case approximately three months apart. It is postulated that a nasal lining of stratified squamous epithelium is likely to be more resistant to trauma than the normal respiratory type, and this is supported by the observation that bleeds very seldom occur from the oral cavity in this syndrome.
本文描述了一种治疗与遗传性出血性毛细血管扩张症相关的严重鼻出血的新技术。将鼻中隔和下鼻甲的呼吸上皮通过手术剥脱，然后用取自颊黏膜上皮培养的上皮片进行自体移植。所有接受该技术治疗的患者鼻出血的频率和严重程度均显著减轻，尽管有两名患者分两次接受移植，每次间隔约三个月。据推测，分层鳞状上皮的鼻内衬可能比正常呼吸型上皮更耐创伤，这一推测得到了如下观察结果的支持：在该综合征中，口腔很少出血。
