Nakao H, Nakajima K, Nakajima S
Department of Virology, Medical School, Nagoya City University, Japan.
J Gen Virol. 1993 Aug;74 ( Pt 8):1667-72. doi: 10.1099/0022-1317-74-8-1667.
The nucleotide sequences of the non-structural protein (NS) and neuraminidase (NA) genes of human influenza A (H2N2) viruses isolated in 1967 and 1968 in Europe, Asia and North and South America were located on evolutionary trees in order to identify the parental virus of Hong Kong influenza A (H3N2) viruses, which appeared in the human population in 1968. From the evolutionary trees, the H2N2 viruses isolated during the 1967 to 1968 period were divided into two groups. Group I includes that A/Tokyo/3/67, A/Hachioji/1/67, A/Perg/1/68, A/Cordoba/522/67, A/Texas/2/68 and A/Berkeley/1/68 viruses, whereas group II includes the A/Georgia/1/67, A/England/10/67 and A/Poland/6/67 viruses. The NS and NA genes of Hong Kong H3N2 viruses isolated in 1968 were genetically closer to those of group II viruses and closest to those of A/Poland/6/67.
为了确定1968年出现在人类群体中的香港甲型流感（H3N2）病毒的亲本病毒，对1967年和1968年在欧洲、亚洲以及南北美洲分离出的人类甲型流感（H2N2）病毒的非结构蛋白（NS）基因和神经氨酸酶（NA）基因的核苷酸序列进行了系统进化树定位。从系统进化树来看，1967年至1968年期间分离出的H2N2病毒被分为两组。第一组包括A/东京/3/67、A/八王子/1/67、A/佩尔格/1/68、A/科尔多瓦/522/67、A/得克萨斯/2/68和A/伯克利/1/68病毒，而第二组包括A/佐治亚/1/67、A/英格兰/10/67和A/波兰/6/67病毒。1968年分离出的香港H3N2病毒的NS基因和NA基因在遗传上更接近第二组病毒，与A/波兰/6/67病毒最为接近。
