Wango E O, Wooding F B, Heap R B
Institute of Primate Research, National Museums of Kenya, Karen, Nairobi.
Placenta. 1990 Sep-Oct;11(5):381-94. doi: 10.1016/s0143-4004(05)80214-0.
The number of goat trophoblastic binucleate cells, the incidence of their migration and the formation of trinucleate and syncytial cells in the maternal uterine epithelial layer was estimated quantitatively using transmission electron microscopy between 14 and 23 days postcoitum (dpc). Binucleate cells were first observed at 18 dpc and their proportions increased rapidly from less than 1 per cent to 16 per cent by 19 dpc and 22 per cent by 23 dpc. The appearance of trinucleate cells within the maternal uterine epithelial layer coincided with evidence of migration and fusion of binucleate cells with individual uterine epithelial cells, and an increased death rate among the other uninucleate uterine epithelial cells. There was also a slight increase in the incidence of intraepithelial lymphocytes close to the trinucleate cells. The quantitative studies uphold the hypothesis that at implantation in the goat, placental trinucleate cells and their subsequent multinucleate syncytial plaque derivatives are fetomaternal hybrid tissue formed by fusion of a binucleate cell(s) with a single uterine epithelial cell.
在交配后14至23天（dpc）期间，使用透射电子显微镜对山羊滋养层双核细胞的数量、其迁移发生率以及母体子宫上皮层中三核细胞和合体细胞的形成进行了定量估计。双核细胞在18 dpc时首次被观察到，其比例从不到1%迅速增加，到19 dpc时达到16%，到23 dpc时达到22%。母体子宫上皮层内三核细胞的出现与双核细胞与单个子宫上皮细胞迁移和融合的证据以及其他单核子宫上皮细胞死亡率增加相一致。靠近三核细胞的上皮内淋巴细胞发生率也略有增加。定量研究支持这样的假设，即在山羊着床时，胎盘三核细胞及其随后的多核合体斑块衍生物是由一个或多个双核细胞与单个子宫上皮细胞融合形成的母胎混合组织。
