Reams G P
University of Missouri School of Medicine, Department of Medicine, Columbia.
J Hum Hypertens. 1993 Jun;7(3):211-9.
Calcium channel blockers are used in the treatment of hypertension because of their ability to decrease peripheral vascular resistance. Recent research has suggested that these drugs also preserve or improve renal function in patients with essential hypertensive renal disease, diabetic renal disease, and in renal transplant recipients with or without cyclosporine therapy. In general, studies in both animal models and humans have demonstrated maintenance or reduction in renal vascular resistance, and preservation or enhancement of renal blood flow and glomerular filtration rate. In addition, calcium channel blockers appear to have a positive effect on renal haemodynamic function in the setting of diabetes mellitus; prospective trials have demonstrated reductions in urinary protein excretion in these patients. Current evidence suggests that calcium channel blockers are well suited for the treatment of patients with hypertensive disease even in the presence of renal impairment.
钙通道阻滞剂因其能够降低外周血管阻力而被用于治疗高血压。最近的研究表明，这些药物还能保护或改善原发性高血压肾病、糖尿病肾病患者以及接受或未接受环孢素治疗的肾移植受者的肾功能。总体而言，动物模型和人体研究均表明，使用钙通道阻滞剂可维持或降低肾血管阻力，保持或增加肾血流量及肾小球滤过率。此外，钙通道阻滞剂似乎对糖尿病患者的肾脏血流动力学功能有积极作用；前瞻性试验已证明，这些患者的尿蛋白排泄量会减少。目前的证据表明，即使存在肾功能损害，钙通道阻滞剂也非常适合用于治疗高血压疾病患者。
