Groen J, van Mastrigt R, van Asselt E, van Koeveringe G A, Bosch R
Department of Urology, Erasmus University Rotterdam, The Netherlands.
J Urol. 1994 May;151(5):1405-10. doi: 10.1016/s0022-5347(17)35269-2.
The parameters P(isv) (active isovolumetric detrusor pressure) and Vmax (maximum shortening velocity), which characterize the contractility of the detrusor muscle, were determined in guinea pigs. To this end it was necessary to develop a method of measuring flow rates in these small animals. The values found were used to calculate the contractility parameter Wmax. Thirteen animals were used. The results found for P(isv) and Vmax were 43.0 +/- 3.7 cm. H2O and 20.2 +/- 3.7 mm. per second, respectively. The latter corresponded to about 0.38 muscle lengths per second, which is similar to values reported for bladder strips from other species. Previous work showed that in vitro P(isv) decreased with increasing bladder volume over a wide range of volumes. In vivo P(isv) seemed to be independent of bladder volume. This suggests that neurogenic stimulation intensifies as volume increases. Vmax also was independent of volume. Wmax appeared to be suitable for detecting differences in the contractility of the bladders of different animals. Values were not significantly different in isovolumetric and nonisovolumetric contractions. Normalized to the size of the bladder, the Wmax values indicated that the power generated by the guinea pig bladder is similar to the power generated by the human bladder.
在豚鼠身上测定了表征逼尿肌收缩性的参数P(isv)（主动等容逼尿肌压力）和Vmax（最大缩短速度）。为此，有必要开发一种测量这些小动物流速的方法。所得到的值用于计算收缩性参数Wmax。使用了13只动物。P(isv)和Vmax的结果分别为43.0±3.7 cmH₂O和20.2±3.7 mm/秒。后者相当于每秒约0.38个肌肉长度，这与其他物种膀胱条带报道的值相似。先前的研究表明，在体外，在很宽的体积范围内，P(isv)随膀胱体积增加而降低。在体内，P(isv)似乎与膀胱体积无关。这表明随着体积增加，神经源性刺激增强。Vmax也与体积无关。Wmax似乎适合检测不同动物膀胱收缩性的差异。等容收缩和非等容收缩的值没有显著差异。将Wmax值按膀胱大小进行归一化后表明，豚鼠膀胱产生的功率与人膀胱产生的功率相似。
