Russell P J, Palavidis Z, Rozinova E, Philips J, Wills E J, Lukeis R, Wass J, Raghavan D
Kanematsu Laboratory, Royal Prince Alfred Hospital, New South Wales, Australia.
J Urol. 1993 Sep;150(3):1038-44. doi: 10.1016/s0022-5347(17)35682-3.
A new human bladder cancer cell line, UCRU-BL-28 has been established and characterized from a relapsed, cisplatin resistant, grade II, stage T4 tumor. This line is tumorigenic in nude mice and reflects the pathology of the original tumor. The morphology, the expression of tumor-associated antigens and EGF receptors, and the ability to grow both in an anchorage independent manner and in the absence of serum is explored. The BL-28 line has 71-74XXY chromosomes, with del 5q, der(9) and i(19q). Further studies on the molecular basis of bladder cancer, chemosensitivity to cisplatin, growth factor production and tissue invasion are under way.
一种新的人膀胱癌细胞系UCRU-BL-28已从一例复发的、顺铂耐药的II级、T4期肿瘤中建立并进行了特征描述。该细胞系在裸鼠中具有致瘤性，并反映了原发肿瘤的病理学特征。对其形态、肿瘤相关抗原和表皮生长因子受体的表达以及在非锚定依赖方式和无血清条件下生长的能力进行了研究。BL-28细胞系具有71 - 74XXY染色体，伴有5号染色体长臂缺失、9号衍生染色体和19号染色体等臂染色体。关于膀胱癌分子基础、对顺铂的化学敏感性、生长因子产生和组织侵袭的进一步研究正在进行中。
