Heckl W, Köhler J, Hoehn H, Dämmrich J
Department of Urology, University of Würzburg, School of Medicine, Federal Republic of Germany.
Urol Res. 1988;16(1):23-9. doi: 10.1007/BF00264624.
A new human transitonal cell carcinoma cell line has been established in long term tissue culture. The BT-1 cells were derived from a poorly differentiated human bladder cancer. The tumor cell line produces tumors in nude mice. BT-1 has been characterized by cytogenetic and flow cytometric analysis and by isoenzyme typing. As in direct preparations of human bladder tumors, an isochromosome 5p is a consistent marker of the newly established line. The BT-1 cells produce transforming growth factors but do not respond to exogeneous EGF.
一种新的人移行细胞癌细胞系已通过长期组织培养建立。BT - 1细胞源自低分化的人膀胱癌。该肿瘤细胞系可在裸鼠体内产生肿瘤。BT - 1已通过细胞遗传学、流式细胞术分析和同工酶分型进行了表征。如同在人膀胱肿瘤的直接制备中一样，5号染色体短臂等臂染色体是新建立细胞系的一个一致标记。BT - 1细胞产生转化生长因子，但对外源性表皮生长因子无反应。
