Miyakawa T, Nakai K, Moriai N, Kamata J, Adachi T, Chiba M, Ogiu N, Kasazuki T, Kato K, Takahashi T
Second Department of Internal Medicine, Iwate Medical University School of Medicine.
Kaku Igaku. 1993 Jun;30(6):669-74.
Exercise myocardial SPECT using 99mTc-Teboroxime was performed and the regions of ischemic area were compared with 201Tl myocardial SPECT in 8 patients with coronary artery disease. All patients had no evidence of previous myocardial infarction, and underwent bicycle ergometer exercise according to a standardized multistage exercise protocol. At peak exercise, 555 MBq 99mTc-Teboroxime or 75 MBq 201Tl was injected intravenously. After termination of exercise, images were obtained with a gamma camera rotating through a 180 degrees arc from 45 degrees right anterior oblique to 45 degrees left posterior oblique. The concordance of 99mTc-Teboroxime SPECT and 201Tl SPECT was 63% in ischemic region and 83% in normal region. Furthermore, one patient underwent dipyridamole infusion and 99mTc-Teboroxime SPECT was carried out. The images obtained by dipyridamole 99mTc-Teboroxime SPECT were equivalent to the images of exercise 201Tl SPECT. 99mTc-Teboroxime SPECT seems useful for the detection of the coronary artery disease. It was suggested that evaluation of the myocardial viability in acute phase of myocardial infarction can be possible by using 99mTc-Teboroxime SPECT.
对8例冠心病患者进行了使用99mTc-替博肟的运动心肌单光子发射计算机断层扫描（SPECT），并将缺血区域与201Tl心肌SPECT进行比较。所有患者均无既往心肌梗死证据，并根据标准化的多级运动方案进行自行车测力计运动。在运动高峰时，静脉注射555 MBq 99mTc-替博肟或75 MBq 201Tl。运动结束后，使用γ相机从右前斜45度到左后斜45度旋转180度弧获取图像。99mTc-替博肟SPECT与201Tl SPECT在缺血区域的一致性为63%，在正常区域为83%。此外，1例患者接受了双嘧达莫输注并进行了99mTc-替博肟SPECT检查。双嘧达莫99mTc-替博肟SPECT获得的图像与运动201Tl SPECT的图像相当。99mTc-替博肟SPECT似乎对检测冠状动脉疾病有用。有人提出，使用99mTc-替博肟SPECT可能对评估心肌梗死急性期的心肌活力。
