Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Soda R, Kiyoshi T, Takahashi K, Kimura I
Department of Medicine, Okayama University Medical School, Tottori.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Jun;31(6):717-24.
Effects of long-term glucocorticoid therapy on airway inflammatory cells were examined in 40 patients with bronchial asthma. 1. The dose of glucocorticoids required by asthmatic patients tended to increase and the level of serum cortisol tended to decrease with prolongation of the period of glucocorticoid therapy. 2. The proportion and number of lymphocytes in bronchoalveolar lavage (BAL) fluid decreased with prolongation of the period of glucocorticoid therapy. The proportion of BAL lymphocytes in asthmatic patients treated with glucocorticoids for more than 5 years was significantly lower than that in those treated for less than 4.9 years. 3. The proportion and number of BAL neutrophils increased with prolongation of the period of glucocorticoid therapy and the proportion of BAL neutrophils in patients treated with glucocorticoids for more than 10 years was significantly higher compared with those treated for less than 9.9 years. These findings indicate that long-term glucocorticoid therapy induces changes in airway inflammatory cell profiles, with a decrease in the number of lymphocytes and increase in the number of neutrophils.
对40例支气管哮喘患者研究了长期糖皮质激素治疗对气道炎症细胞的影响。1. 随着糖皮质激素治疗时间的延长，哮喘患者所需糖皮质激素剂量有增加趋势，血清皮质醇水平有下降趋势。2. 支气管肺泡灌洗（BAL）液中淋巴细胞的比例和数量随糖皮质激素治疗时间的延长而降低。接受糖皮质激素治疗超过5年的哮喘患者BAL淋巴细胞比例显著低于治疗时间不足4.9年的患者。3. BAL中性粒细胞的比例和数量随糖皮质激素治疗时间的延长而增加，接受糖皮质激素治疗超过10年的患者BAL中性粒细胞比例显著高于治疗时间不足9.9年的患者。这些发现表明，长期糖皮质激素治疗可引起气道炎症细胞谱的变化，淋巴细胞数量减少，中性粒细胞数量增加。
