Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Soda R, Tada S, Takahashi K, Kimura I
Department of Medicine, Misasa Medical Branch, Okayama University Medical School, Misasa Tottori, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Apr;31(4):459-64.
The correlation between proportions of cells in bronchoalveolar lavage (BAL) fluid and ventilatory function was examined in 52 patients with asthma. 1. There was no significant correlation between the proportion of BAL lymphocytes and ventilatory function. 2. The proportion of BAL eosinophils correlated to a certain extent with ventilatory function: the values of %MMF, %V50 and %V25 were lower in patients with BAL eosinophils of 10-19.9% than in those with BAL eosinophils below 4.9%, and %V25 value was significantly lower in patients with a high proportion of BAL eosinophils (10-19.9%) compared with those with a low proportion of BAL eosinophils (0-4.9%). However, ventilatory function was not decreased in patients with BAL eosinophils of more than 20%. 3. The values of ventilatory parameters showed a tendency to decrease with increase in BAL neutrophils. The values of all parameters of obstructive ventilatory dysfunction were significantly lower in patients with BAL neutrophils of > 10% than in those with BAL neutrophils < 4.9%. A significant difference between patients with BAL neutrophils > 10% and < 9.9% was found in values of %V50 and %V25, and the values of %V50 and %V25 were significantly lower in patients with a high proportion of BAL neutrophils (> 10%) than in those with BAL neutrophils < 9.9%. These results suggest that the proportion of BAL eosinophils is to a certain extent related to ventilatory function of asthma patients and that the increase in proportion of BAL neutrophils is closely related to a decrease in values of obstructive ventilatory parameters.
对52例哮喘患者支气管肺泡灌洗（BAL）液中的细胞比例与通气功能之间的相关性进行了研究。1. BAL淋巴细胞比例与通气功能之间无显著相关性。2. BAL嗜酸性粒细胞比例与通气功能在一定程度上相关：BAL嗜酸性粒细胞比例为10 - 19.9%的患者，其%MMF、%V50和%V25值低于BAL嗜酸性粒细胞比例低于4.9%的患者，且BAL嗜酸性粒细胞比例高（10 - 19.9%）的患者的%V25值显著低于BAL嗜酸性粒细胞比例低（0 - 4.9%）的患者。然而，BAL嗜酸性粒细胞比例超过20%的患者通气功能并未降低。3. 通气参数值显示出随BAL中性粒细胞增加而降低的趋势。BAL中性粒细胞> 10%的患者，其阻塞性通气功能障碍的所有参数值均显著低于BAL中性粒细胞< 4.9%的患者。在BAL中性粒细胞> 10%和< 9.9%的患者之间，%V50和%V25值存在显著差异，且BAL中性粒细胞比例高（> 10%）的患者的%V50和%V25值显著低于BAL中性粒细胞比例< 9.9%的患者。这些结果表明，BAL嗜酸性粒细胞比例在一定程度上与哮喘患者的通气功能相关，且BAL中性粒细胞比例的增加与阻塞性通气参数值的降低密切相关。
