Ebisuno S, Ohkawa T, Scheid C, Menon M
Department of Urology, Minami Wakayama National Hospital.
Nihon Hinyokika Gakkai Zasshi. 1993 Jun;84(6):1082-7. doi: 10.5980/jpnjurol1989.84.1082.
The oxalate uptake was studied in LLC-PK1 cells, an epithelial cell line originated in proximal tubular cells of porcine kidney. It was clear that the cells contain an oxalate exchanger highly sensitive to 4,4-diisothio-cyanostilbene-2-' disulfonic acid (DIDS). The uptake was inhibited by the addition of inorganic anions (chloride, sulphate and bicarbonate) to the reaction system, but was unaffected by sodium ion. The data suggest the possibility that it should be consistent with at least two transport systems for oxalate in LLC-PK1 cells, a SO4-/oxalate/HCO3- exchanger and a Cl-/oxalate exchanger.
在LLC-PK1细胞（一种源自猪肾近端肾小管细胞的上皮细胞系）中研究了草酸盐摄取情况。很明显，这些细胞含有一种对4,4 - 二异硫氰基芪 - 2,2'-二磺酸（DIDS）高度敏感的草酸盐交换体。向反应体系中添加无机阴离子（氯离子、硫酸根离子和碳酸氢根离子）会抑制摄取，但不受钠离子影响。数据表明，LLC-PK1细胞中草酸盐的转运系统可能至少有两种，一种是SO4-/草酸盐/HCO3-交换体，另一种是Cl-/草酸盐交换体。
