Page R C, Walravens E K, Levy J C, Stratton I M, Turner R C
Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK.
Metabolism. 1993 Aug;42(8):932-8. doi: 10.1016/0026-0495(93)90003-7.
Insulin resistance and beta-cell function were assessed by a continuous infusion of glucose in the following three groups of white subjects at risk of developing impaired glucose tolerance and diabetes: 41 subjects who were the offspring of patients with type II diabetes, 26 general-population subjects with an increased fasting plasma glucose level of at least 5.6 mmol/L on screening, and 22 subjects who had had gestational diabetes but were now nondiabetic. Subjects had a mean (+/- 1 SD) age of 43 +/- 9 years and a body mass index (BMI) of 27 +/- 5 kg/m2. Subjects with previously increased fasting glucose levels were significantly more insulin resistant than a control group, taking into account BMI, age, and gender (% normal insulin sensitivity [%], 59 [50 to 79] v 87 [73 to 96]; P < .005), and previously gestationally diabetic subjects showed greater impairment of beta-cell function (% normal beta-cell function [% beta], 69 [60 to 87] v 97 [89 to 105]; P < .005). Diabetes (defined by World Health Organization criteria) or impaired glucose tolerance (defined as an achieved plasma glucose concentration [APG] > 95th percentile of an age- and weight-matched population) was identified in 22% of family members, 31% of fasting hyperglycemic subjects, and 41% of previously gestationally diabetic subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
通过连续输注葡萄糖，对以下三组有糖耐量受损和糖尿病风险的白人受试者评估胰岛素抵抗和β细胞功能：41名2型糖尿病患者的后代、26名筛查时空腹血糖水平至少为5.6 mmol/L的普通人群受试者以及22名曾患妊娠期糖尿病但目前非糖尿病的受试者。受试者的平均（±1标准差）年龄为43±9岁，体重指数（BMI）为27±5 kg/m²。考虑到BMI、年龄和性别，既往空腹血糖水平升高的受试者比对照组胰岛素抵抗明显更严重（正常胰岛素敏感性百分比[％]，59[50至79]对87[73至96]；P<0.005），既往患妊娠期糖尿病的受试者β细胞功能损害更大（正常β细胞功能百分比[％β]，69[60至87]对97[89至105]；P<0.005）。根据世界卫生组织标准定义的糖尿病或糖耐量受损（定义为达到的血浆葡萄糖浓度[APG]>年龄和体重匹配人群的第95百分位数）在22％的家庭成员、31％的空腹血糖高的受试者和41％的既往患妊娠期糖尿病的受试者中被识别出来。（摘要截断于250字）
