Balmer A, Gailloud C, Munier F, Uffer S, Guex-Crosier Y
Jules Gonin Eye Hospital, Lausanne, Switzerland.
Ophthalmic Paediatr Genet. 1993 Mar;14(1):33-8. doi: 10.3109/13816819309087621.
Three clinical cases have been chosen to illustrate the pitfalls that can be encountered when warning signs other than leukokoria or strabismus indicate possible retinoblastoma. The first case, a four-year-old boy, was admitted to hospital after an accident, presenting uveitis, glaucoma and a subluxated lens. He was suffering from unilateral retinoblastoma, already exteriorized and the cause of death some months later. The second case, and 11-month-old female child was seen on fundus examination to present a yellowish elevated calcified mass which turned out to be tuberous sclerosis. The third patient, a 43-year-old male, father of two children suffering from retinoblastoma, was found on routine examination to be carrying a partially-calcified retinal tumour. Subsequent haemorrhaging rendered enucleation necessary and microscopic examination confirmed the diagnosis of retinoma. The diagnosis of retinoblastoma should always be kept in mind whenever an intraocular mass is revealed or where there are unexplained atypical ocular signs.
选取了三个临床病例来说明，当除白瞳症或斜视之外的警示信号提示可能患有视网膜母细胞瘤时可能会遇到的陷阱。第一个病例是一名4岁男孩，在一次事故后入院，表现为葡萄膜炎、青光眼和晶状体半脱位。他患有单侧视网膜母细胞瘤，肿瘤已外露，几个月后死亡。第二个病例是一名11个月大的女童，眼底检查发现有一个淡黄色的隆起钙化肿块，结果是结节性硬化症。第三个患者是一名43岁男性，是两个患有视网膜母细胞瘤孩子的父亲，在常规检查中发现其有一个部分钙化的视网膜肿瘤。随后的出血使得有必要进行眼球摘除，显微镜检查确诊为视网膜瘤。每当发现眼内肿块或出现无法解释的非典型眼部体征时，都应始终牢记视网膜母细胞瘤的诊断。
