Valencia G B, Banzon F, Cummings M, McCormack W M, Glass L, Hammerschlag M R
Department of Pediatrics, Children's Medical Center, State University of New York, Health Science Center, Brooklyn.
Pediatr Infect Dis J. 1993 Jul;12(7):571-3. doi: 10.1097/00006454-199307000-00004.
The role of genital mycoplasmas in the pathogenesis of neonatal infection is incompletely understood. We performed nasopharyngeal, blood and cerebrospinal fluid (CSF) cultures for Mycoplasma hominis and Ureaplasma urealyticum in 69 neonates who underwent a diagnostic workup for suspected sepsis. The mean gestational age was 35.9 weeks (range, 25 to 42 weeks) with a mean birth weight of 2386 g (range, 652 to 4420 g). Twenty-seven infants (39.1%) had positive nasopharyngeal cultures; 6 were positive for M. hominis, 10 for U. urealyticum and 11 for both organisms. Seven (26%) of these 27 patients developed chronic lung disease compared with 2 (4.7%) infants in the non-colonized group. Nine infants had positive CSF cultures for M. hominis and one infant had a positive CSF culture for U. urealyticum. All blood cultures were sterile. One of the infants with a positive CSF culture for M. hominis had clinical evidence of systemic infection. All of the infants were treated with antibiotic agents that were not active against mycoplasmas. These data indicate that genital mycoplasmas can be found commonly in the CSF and nasopharynx of infants with suspected sepsis. Their etiologic role in the causation of infection and chronic lung disease, however, remains unclear.
生殖支原体在新生儿感染发病机制中的作用尚未完全明确。我们对69例因疑似败血症接受诊断性检查的新生儿进行了人型支原体和解脲脲原体的鼻咽、血液及脑脊液（CSF）培养。平均胎龄为35.9周（范围25至42周），平均出生体重为2386克（范围652至4420克）。27例婴儿（39.1%）鼻咽培养呈阳性；6例人型支原体阳性，10例解脲脲原体阳性，11例两种病原体均阳性。这27例患者中有7例（26%）发生了慢性肺病，而非定植组中有2例婴儿（4.7%）发生慢性肺病。9例婴儿脑脊液中人型支原体培养呈阳性，1例婴儿脑脊液中解脲脲原体培养呈阳性。所有血培养均无菌。1例脑脊液中人型支原体培养阳性的婴儿有全身感染的临床证据。所有婴儿均接受了对支原体无活性的抗生素治疗。这些数据表明，在疑似败血症的婴儿脑脊液和鼻咽中常见生殖支原体。然而，它们在感染和慢性肺病病因中的作用仍不清楚。
