Izraeli S, Samra Z, Sirota L, Merlob P, Davidson S
Department of Neonatology, Beilinson Medical Centre, Petach-Tiqva, Israel.
Eur J Pediatr. 1991 Sep;150(11):804-7. doi: 10.1007/BF02026717.
The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have recently assumed an increasing importance as neonatal pathogens. The aim of the present survey was to determine the prevalence of infections with these organisms in preterm infants in two neonatal intensive care units in Israel. Among 99 preterm infants, 24 (24%) harboured mycoplasmas in their throats shortly after birth. U. urealyticum was the most common organism. M. hominis was isolated only from 3 infants. Six out of 27 (22%) mechanically ventilated infants secreted U. urealyticum in their lower airways. The rate of colonization was inversely correlated with gestational age; 80% of infants younger than 28 weeks gestation were found to be colonized as opposed to 17.9% at 28-36 weeks of gestation. No mycoplasmas were isolated in blood cultures drawn from 146 infants and CSF cultures obtained from 47 preterm infants. Neonatal mortality, respiratory complications and intraventricular haemorrhage grade 3-4 were significantly increased in colonized infants. However, above gestational age of 27 weeks, colonization with mycoplasmas was not associated with a worse prognosis. We conclude that colonization with U. urealyticum is common in Israeli preterm infants, correlates inversely with gestational age and has no detrimental effect on neonatal morbidity and mortality of infants older than 27 wks of gestation.
解脲脲原体和人型支原体作为新生儿病原体，其重要性近来日益增加。本调查的目的是确定以色列两个新生儿重症监护病房中早产儿感染这些病原体的发生率。在99名早产儿中，24名（24%）在出生后不久咽部带有支原体。解脲脲原体是最常见的病原体。仅从3名婴儿中分离出人型支原体。27名机械通气婴儿中有6名（22%）在下呼吸道分泌了解脲脲原体。定植率与胎龄呈负相关；胎龄小于28周的婴儿中80%被发现有定植，而胎龄在28 - 36周的婴儿中这一比例为17.9%。从146名婴儿抽取的血培养物以及从47名早产儿获得的脑脊液培养物中均未分离出支原体。定植婴儿的新生儿死亡率、呼吸并发症和3 - 4级脑室内出血显著增加。然而，胎龄超过27周后，支原体定植与预后较差无关。我们得出结论，解脲脲原体定植在以色列早产儿中很常见，与胎龄呈负相关，并且对胎龄超过27周的婴儿的新生儿发病率和死亡率没有不利影响。
