Qureshi M A, Petitte J N, Laster S M, Dietert R R
Department of Poultry Science, North Carolina State University, Raleigh 27695.
Poult Sci. 1993 Jul;72(7):1280-4. doi: 10.3382/ps.0721280.
The capacity of macrophages to generate metabolites and monokines having effector and regulatory functions can result in a major impact on their cellular microenvironment. Macrophage products synthesized in response to bacterial lipopolysaccharide stimulation include reactive oxygen and nitrogen intermediates as well as tumor necrosis factor (TNF). These secreted products of macrophages exhibit bioactivity either locally or systemically. Although the mechanism of action of avian monokines such as TNF-like factor may be similar to their mammalian counterparts, chicken TNF seems to lyse cells of chicken origin and not of mammalian origin. Furthermore, the generation and activity of products such as TNF is directly influenced by environmental stressors such as heat and toxins.
巨噬细胞产生具有效应和调节功能的代谢产物和单核因子的能力，可对其细胞微环境产生重大影响。巨噬细胞在细菌脂多糖刺激下合成的产物包括活性氧和氮中间体以及肿瘤坏死因子（TNF）。巨噬细胞分泌的这些产物在局部或全身都具有生物活性。尽管禽类单核因子如TNF样因子的作用机制可能与其哺乳动物对应物相似，但鸡TNF似乎能裂解鸡源细胞而非哺乳动物源细胞。此外，TNF等产物的产生和活性直接受到热和毒素等环境应激因素的影响。
