Lo S C, Hayes M M, Kotani H, Pierce P F, Wear D J, Newton P B, Tully J G, Shih J W
Department of Infectious and Parasitic Diseases Pathology, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, D.C.
Mod Pathol. 1993 May;6(3):276-80.
The newly identified mycoplasma, Mycoplasma pentrans shows remarkable pathobiologic properties: it adheres to cell surfaces, deeply penetrates into the cell, strongly hemadsorbs human red blood cells, and cytadsorbs human CD4+ lymphocytes and monocytes. These in vitro biologic activities of mycoplasmas have been previously shown to be associated with pathogenic virulence in vivo. Both adhesion and invasion clearly involve the organism's unique tip-like structure. Invading mycoplasmas often have their tip-like structure deeply buried in the cytoplasm of infected mammalian cells. Extensive invasion of the mycoplasma into the cytoplasm may kill the cells. The same pathobiologic processes of adhesion and invasion using the specialized tip-like structure are found on the epithelium in the patient's urogenital tract infected by M. penetrans. Both in vitro and in vivo findings suggest a possible pathogenic role of this newly discovered human mycoplasma and call for careful evaluation of its role in human diseases.
新鉴定出的支原体，即五日热支原体，表现出显著的病理生物学特性：它能黏附于细胞表面，深入细胞内部，强烈吸附人红细胞，并吸附人CD4+淋巴细胞和单核细胞。支原体的这些体外生物学活性先前已被证明与体内致病毒力相关。黏附和侵入显然都涉及该生物体独特的尖端样结构。侵入的支原体通常将其尖端样结构深深埋入被感染哺乳动物细胞的细胞质中。支原体大量侵入细胞质可能会杀死细胞。在穿透支原体感染的患者泌尿生殖道上皮中也发现了利用这种特殊尖端样结构进行黏附和侵入的相同病理生物学过程。体外和体内的研究结果均表明这种新发现的人支原体可能具有致病作用，因此需要仔细评估其在人类疾病中的作用。
