Benedetti Francesca, Curreli Sabrina, Krishnan Selvi, Davinelli Sergio, Cocchi Fiorenza, Scapagnini Giovanni, Gallo Robert C, Zella Davide
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Department of Medicine and Health Sciences, University of Molise, 86100, Campobasso, Italy.
J Transl Med. 2017 May 10;15(1):100. doi: 10.1186/s12967-017-1206-8.
Hydrogen sulfide (HS), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human tissues. As demonstrated in recent studies, HS is produced endogenously in response to different cellular stimuli and plays different roles in controlling a number of physiological responses. The precise role of HS in inflammation is still largely unknown. In particular, the role of HS in the regulation of the inflammatory response in acute and chronic infections is being actively investigated because of its potential therapeutic use. To study the effect of HS as an anti-inflammatory mediator during bacterial infections, we developed an ex vivo model of primary cells and cell lines infected with Mycoplasma. Our data demonstrate a dichotomic effect of HS on the NF-kB and Nrf-2 molecular pathways, which were inhibited and stimulated, respectively.
硫化氢（HS），以前仅被视为一种有毒的环境空气污染物，现在越来越被认为是一种重要的信号分子，能够调节许多人体组织中的多种细胞途径。正如最近的研究所表明的，HS是在不同细胞刺激下内源性产生的，并且在控制许多生理反应中发挥不同作用。HS在炎症中的精确作用仍然很大程度上未知。特别是，由于其潜在的治疗用途，HS在急性和慢性感染中炎症反应调节中的作用正在被积极研究。为了研究HS作为细菌感染期间抗炎介质的作用，我们建立了一个感染支原体的原代细胞和细胞系的体外模型。我们的数据表明HS对NF-kB和Nrf-2分子途径具有二分效应，分别被抑制和刺激。
