成年囊性纤维化患者的骨矿物质密度和身体成分
Bone mineral density and body composition in adult patients with cystic fibrosis.
作者信息
Grey A B, Ames R W, Matthews R D, Reid I R
机构信息
Department of Medicine, University of Auckland, New Zealand.
出版信息
Thorax. 1993 Jun;48(6):589-93. doi: 10.1136/thx.48.6.589.
BACKGROUND
Cystic fibrosis is a multisystem disease characterised by chronic pulmonary sepsis and malnutrition. To ascertain whether osteoporosis is a feature of cystic fibrosis in adult patients, total body and regional bone mineral density (BMD) was measured in a group of eight men and eight women aged 17-42 years.
METHODS
Total body and regional BMD (lumbar spine L2-L4, femoral neck, trochanteric, and Ward's triangle), as well as total body fat and lean mass, were measured by dual energy x ray absorptiometry. A range of biochemical, lifestyle, and anthropometric variables was also assessed.
RESULTS
Patients with cystic fibrosis had significantly reduced bone density at all sites compared with normal young adults. The mean reductions ranged from 7% at Ward's triangle to 13% at the trochanter. Body mass index (BMI) was positively correlated with BMD at four sites and disease severity negatively correlated with BMD at two sites. Other biochemical and anthropometric variables were not predictive of bone density. Total body fat mass was reduced by 30% compared with normal young adults.
CONCLUSIONS
Bone density is decreased in adult patients with cystic fibrosis and BMI and disease severity are independent predictors of bone density.
背景
囊性纤维化是一种多系统疾病，其特征为慢性肺脓毒症和营养不良。为确定骨质疏松是否为成年囊性纤维化患者的一个特征，对一组年龄在17至42岁的8名男性和8名女性进行了全身和局部骨矿物质密度（BMD）测量。
方法
采用双能X线吸收法测量全身和局部BMD（腰椎L2-L4、股骨颈、大转子和沃德三角区），以及全身脂肪和瘦体重。还评估了一系列生化、生活方式和人体测量学变量。
结果
与正常年轻成年人相比，囊性纤维化患者所有部位的骨密度均显著降低。平均降低幅度从沃德三角区的7%到转子区的13%不等。体重指数（BMI）与四个部位的BMD呈正相关，疾病严重程度与两个部位的BMD呈负相关。其他生化和人体测量学变量不能预测骨密度。与正常年轻成年人相比，全身脂肪量减少了30%。
结论
成年囊性纤维化患者骨密度降低，BMI和疾病严重程度是骨密度的独立预测因素。
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