采用聚合酶链反应技术对霍奇金病患者的HLA-DPβ1基因座进行研究。
Study of the HLA-DP beta 1 locus by the polymerase chain reaction technique in patients with Hodgkin's disease.
作者信息
Pellegris G, Lombardo C, Cantoni A, Devizzi L, Balzarotti M
机构信息
Division of Immunohematology, Istituto Nazionale Tumori, Milano, Italy.
出版信息
Tumori. 1993 Apr 30;79(2):133-6. doi: 10.1177/030089169307900211.
BACKGROUND
A number of reports have studied associations between Hodgkin's disease and HLA. Some of them established correlation between several antigens and Hodgkin's disease, and others found no correlations.
METHODS
The HLA DP locus was determined by the polymerase chain reaction method in 31 Hodgkin's disease patients and 58 healthy controls.
RESULTS
No significant difference between patients and controls was noted.
CONCLUSIONS
Further investigations are needed to confirm the hypothesis of a possible role of the HLA complex as one of the factors involved in Hodgkin's disease.
背景
已有多篇报道研究了霍奇金病与人类白细胞抗原（HLA）之间的关联。其中一些研究确定了几种抗原与霍奇金病之间的相关性，而其他研究则未发现相关性。
方法
采用聚合酶链反应法对31例霍奇金病患者和58例健康对照者进行HLA-DP位点检测。
结果
患者与对照者之间未发现显著差异。
结论
需要进一步研究以证实HLA复合体作为参与霍奇金病发病因素之一的假说。
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