Singh I P, Coppenhaver D H, Chopra A K, Baron S
Department of Microbiology, University of Texas Medical Branch, Galveston.
J Biol Regul Homeost Agents. 1993 Jan-Mar;7(1):7-14.
This study compares the characteristics of naturally occurring antiviral activities in nonhuman mammalian sera to UTI beta (University of Texas virus inhibitor beta), an innate, non-specific viral inhibitor found in human serum. The antiviral agent in sera from four different species appears to possess properties similar to those of UTI beta, e.g. molecular weight of 60 +/- 10 kDa, broad spectrum antiviral activity, glycoprotein structure with antiviral oligosaccharide moiety(s) attached to a carrier protein, and inhibition of most viruses by preventing their attachment to target cells. These findings suggest that UTI beta or UTI beta-like virus inhibitors are a normal component of the non-specific immune defenses of mammals.
本研究将非人类哺乳动物血清中天然存在的抗病毒活性特征与UTIβ（德克萨斯大学病毒抑制剂β）进行了比较，UTIβ是一种存在于人类血清中的先天性非特异性病毒抑制剂。来自四种不同物种血清中的抗病毒剂似乎具有与UTIβ相似的特性，例如分子量为60±10 kDa、广谱抗病毒活性、具有连接到载体蛋白上的抗病毒寡糖部分的糖蛋白结构，以及通过阻止病毒附着于靶细胞来抑制大多数病毒。这些发现表明，UTIβ或类似UTIβ的病毒抑制剂是哺乳动物非特异性免疫防御的正常组成部分。
