Masuzawa M
Dept. of Dermatology, Kitasato University School of Medicine.
Gan To Kagaku Ryoho. 1993 Aug;20(10):1314-9.
A common type of angiosarcoma in the dermatological field is Wilson-Jones type angiosarcoma arising on the head and neck of elderly. It is called malignant hemangioendothelioma (MHE) and its prognosis is extremely poor, even though treated with the present state of the art: surgical excision, radiation, chemotherapy, and immunotherapy. Recently, chemotherapy has been done with CYVADIC (CPM, VCR, ADM, DTIC), and in some cases intraarterial fusion of ADM and 5-FU has been tried in combination therapy. But older patients are particularly intolerant of this chemotherapy, because of its severe toxic effects. Unfortunately, there is no evidence that these chemotherapeutic trials have helped to improve the prognosis.
在皮肤科领域，一种常见的血管肉瘤类型是发生于老年人头颈部的威尔逊-琼斯型血管肉瘤。它被称为恶性血管内皮瘤（MHE），即便采用当前的先进治疗手段，即手术切除、放疗、化疗和免疫治疗，其预后依然极差。近来，采用CYVADIC（环磷酰胺、长春新碱、多柔比星、达卡巴嗪）进行化疗，在某些病例中还尝试在联合治疗中采用多柔比星与5-氟尿嘧啶动脉内融合的方法。但老年患者对这种化疗尤其不耐受，因为其毒性作用严重。遗憾的是，尚无证据表明这些化疗试验有助于改善预后。
