Akiyama Y, Suzuki T, Hara K, Ishibashi T, Katagiri T, Imai F, Ohno S, Tanaka M, Dohi Y
Second Department of Internal Medicine, Saitama Medical School.
Arerugi. 1993 Jun;42(6):766-72.
The morphological findings and functions of peripheral blood dendritic cells (DC) from patients with mixed connective tissue disease (MCTD) were compared with those of DC from normal subjects. DC from both groups possessed typical dendritic processes and showed HLA-DR antigens and C3bi receptor. The autologous mixed lymphocyte reaction (MLR) and autologous concanavalin A (Con A)-induced T cell proliferation using DC as stimulating cells and accessory cells were significantly depressed in patients with MCTD. In the allogeneic MLR and allogeneic Con A responses, DC from patients with MCTD were poorer stimulating cells and accessory cells. The dysfunction of DC also, as one of the various immune abnormalities, must play a role in the appearance of clinical features.
将混合性结缔组织病（MCTD）患者外周血树突状细胞（DC）的形态学表现及功能与正常受试者的DC进行了比较。两组的DC均具有典型的树突状突起，并表达HLA - DR抗原和C3bi受体。以DC作为刺激细胞和辅助细胞时，MCTD患者的自体混合淋巴细胞反应（MLR）及自体刀豆蛋白A（Con A）诱导的T细胞增殖明显受抑。在同种异体MLR和同种异体Con A反应中，MCTD患者的DC作为刺激细胞和辅助细胞的能力较差。DC功能障碍作为各种免疫异常之一，必定在临床特征的出现中起作用。
