Schalinske K L, Steele R D
Department of Nutritional Sciences, University of Wisconsin-Madison 53706.
Biochem Pharmacol. 1993 Jul 20;46(2):319-25. doi: 10.1016/0006-2952(93)90421-r.
The effect of administration of 13-cis-retinoic acid (100 mg/kg diet) on lipid metabolism was examined in male rats fed either a 20% casein + 0.3% methionine diet, a 20% casein diet, a 10% casein + 0.3% methionine diet, or a 10% casein + 0.6% methionine diet for 10 days. Hepatic triglyceride concentrations of rats fed either 10% casein diet were 3-fold greater than animals receiving diets containing 20% casein. The addition of 13-cis-retinoic acid to the diet further increased the total hepatic lipid (43-56%) and triglyceride (approximately 2-fold) concentrations in rats fed the 10% casein diets. 13-cis-Retinoic acid supplementation did not alter the total liver lipid or triglyceride concentrations in rats fed either of the 20% casein diets. Thus, under specific dietary conditions, the administration of 13-cis-retinoic acid resulted in a marked accumulation of hepatic lipids which did not appear to be related to the total methionine content of the diet nor to the hepatic concentrations of S-adenosylmethionine and glutathione. In addition, all four groups of 13-cis-retinoic acid-fed rats exhibited elevations in the concentration of serum triglycerides, and 10-20% reductions in serum cholesterol concentrations.
在以20%酪蛋白 + 0.3%蛋氨酸饮食、20%酪蛋白饮食、10%酪蛋白 + 0.3%蛋氨酸饮食或10%酪蛋白 + 0.6%蛋氨酸饮食喂养10天的雄性大鼠中，研究了给予13 - 顺式维甲酸（100毫克/千克饮食）对脂质代谢的影响。食用10%酪蛋白饮食的大鼠肝脏甘油三酯浓度比食用含20%酪蛋白饮食的动物高3倍。在食用10%酪蛋白饮食的大鼠中，向饮食中添加13 - 顺式维甲酸进一步增加了肝脏总脂质（43 - 56%）和甘油三酯（约2倍）浓度。补充13 - 顺式维甲酸并未改变食用两种20%酪蛋白饮食之一的大鼠肝脏总脂质或甘油三酯浓度。因此，在特定饮食条件下，给予13 - 顺式维甲酸会导致肝脏脂质明显蓄积，这似乎与饮食中蛋氨酸的总量以及肝脏中S - 腺苷甲硫氨酸和谷胱甘肽的浓度无关。此外，所有四组喂食13 - 顺式维甲酸的大鼠血清甘油三酯浓度均升高，血清胆固醇浓度降低10 - 20%。
