Malissen B, Schmitt-Verhulst A M
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
Curr Opin Immunol. 1993 Jun;5(3):324-33. doi: 10.1016/0952-7915(93)90049-x.
Recent data support the existence of activation motifs within different subunits of the T-cell-receptor-CD3 complex. This architecture generates a receptor composed of discrete modules, each capable of being coupled to an effector pathway. Although new T-cell specific protein tyrosine kinases have recently been identified, the nature of the proximal non-receptor protein tyrosine kinase linking the T-cell receptor complex to essential signalling effectors remains unknown. Developmentally regulated differences in T-cell-receptor-CD3 assembly or stability may lead to the expression of isoforms displaying different sets of activation motifs. Whether this may be the basis of differential signalling during T-cell development is still a matter of speculation.
近期数据支持T细胞受体-CD3复合物不同亚基中存在激活基序。这种结构产生了一种由离散模块组成的受体，每个模块都能够与效应器途径偶联。尽管最近已鉴定出新型T细胞特异性蛋白酪氨酸激酶，但将T细胞受体复合物与重要信号效应器连接的近端非受体蛋白酪氨酸激酶的性质仍然未知。T细胞受体-CD3组装或稳定性在发育过程中的调控差异可能导致显示不同激活基序组的异构体表达。这是否可能是T细胞发育过程中差异信号传导的基础仍有待推测。
