Hirmand H, Latrenta G S, Hoffman L A
Department of Surgery, New York Hospital, Cornell Medical Center.
Oncology (Williston Park). 1993 Jul;7(7):17-24; discussion 24, 28, 30.
An association between crystalline silica and immune disease has long been recognized. However, despite ongoing case reports of systemic autoimmune disease in silicone implant recipients, the available data has not been sufficient to prove or disprove a causal relationship. Silicone has been shown to "bleed" from the implants and can migrate to distant sites. There is evidence of cellular and humoral immune responses to silicone in vivo, but the role of these responses in the development of connective tissue disorders has not been determined. Further studies are necessary to elucidate the role of silicone, if any, in the pathogenesis of autoimmune connective tissue disease. Meanwhile, the implant population needs to be closely monitored; their clinical management should be based on a case by case evaluation.
长期以来，人们一直认识到结晶二氧化硅与免疫疾病之间存在关联。然而，尽管不断有关于硅胶植入物接受者发生全身性自身免疫疾病的病例报告，但现有数据仍不足以证实或否定因果关系。已表明硅胶会从植入物中“渗出”并可迁移至远处部位。有证据表明体内对硅胶存在细胞和体液免疫反应，但这些反应在结缔组织疾病发生过程中的作用尚未确定。有必要进行进一步研究以阐明硅胶在自身免疫性结缔组织疾病发病机制中的作用（若有作用的话）。同时，需要对植入人群进行密切监测；其临床管理应基于个案评估。
