Schubert R, Joos M, Deicher M, Magerle R, Lasch J
Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen, Germany.
Biochim Biophys Acta. 1993 Aug 15;1150(2):162-4. doi: 10.1016/0005-2736(93)90085-e.
Unilamellar and oligolamellar liposomes were topically applied to the skin of porcine ears. Perturbed angular correlation spectroscopy of 111In-DTPA, initially entrapped into the liposomes, was used to study the release kinetics of the hydrophilic probe. After drying of the liposomal suspensions, a decrease of the time-integrated perturbation factor <G22(infinity)> within 30 min indicated destabilization of the liposomes and total marker release in the upper epidermal layers.
将单层和多层脂质体局部应用于猪耳皮肤。最初包封在脂质体中的铟-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（111In-DTPA）的扰动角关联光谱用于研究亲水性探针的释放动力学。脂质体悬浮液干燥后，30分钟内时间积分扰动因子<G22(∞)>的降低表明脂质体不稳定，且标记物在上表皮层完全释放。
