Cuneo A, Ferrant A, Michaux J L, Boogaerts M, Demuynck H, Bosly A, Doyen C, Carli M G, Piva N, Castoldi G
Institute of Hematology, University of Ferrara, Italy.
Leuk Lymphoma. 1993 Mar;9(4-5):285-91. doi: 10.3109/10428199309148525.
Cytogenetic patterns in correlation with cytologic, biomolecular and clinical findings were studied in 45 adult patients with AML expressing at least one of the following lymphoid associated markers (LM): CD2, CD7, CD10, CD19, CD22, TdT. Four cytogenetic groups were recognized: group I, including 8 patients with 11q23 rearrangements; group II including 5 patients with the Ph chromosome; group III, with 19 patients and aberrations of the "myeloid type" including 4 cases with aberrations of chromosome 13, 3 cases with 1q and 7q anomalies, 2 cases with trisomy 11q; group IV, including 13 patients with normal karyotype. Patients showing extensive lineage infidelity were encountered more frequently in cytogenetic groups I and II than in groups III and IV. Two of 4 cases with aberrations of chromosome 13 showed two or more lymphoid features either at immunophenotyping or at biomolecular analysis of the configuration of lg and TCR genes. Patients with 11q23 rearrangements and with the Ph chromosome were generally young, presented with high WBC count and had low complete remission rate. Survival in Ph chromosome positive patients was uniformly short. We conclude that, although there is no cytogenetic anomaly specific for AML with LM, chromosome findings may be clinically relevant in AML with LM. A morphologic, immunologic and cytogenetic classification of AML with LM may constitute a working basis for future studies aimed at a better definition of clinicopathological features and optimal treatment strategy for these leukemias.
对45例表达至少一种下列淋巴样相关标志物（LM）的成年急性髓系白血病（AML）患者，研究了与细胞学、生物分子学及临床发现相关的细胞遗传学模式。这些标志物包括：CD2、CD7、CD10、CD19、CD22、末端脱氧核苷酸转移酶（TdT）。识别出四个细胞遗传学组：第一组，包括8例有11q23重排的患者；第二组，包括5例有费城染色体的患者；第三组，有19例患者，存在“髓系类型”的畸变，包括4例有13号染色体畸变的病例、3例有1q和7q异常的病例、2例有11q三体的病例；第四组，包括13例核型正常的患者。细胞遗传学第一组和第二组中出现广泛谱系不忠实的患者比第三组和第四组更常见。13号染色体畸变的4例病例中，有2例在免疫表型分析或lg和TCR基因构型的生物分子分析中表现出两种或更多种淋巴样特征。有11q23重排和有费城染色体的患者通常较年轻，白细胞计数高，完全缓解率低。费城染色体阳性患者的生存期普遍较短。我们得出结论，虽然没有特定于伴有LM的AML的细胞遗传学异常，但细胞遗传学结果在伴有LM的AML中可能具有临床相关性。伴有LM的AML的形态学、免疫学和细胞遗传学分类可能为未来旨在更好地定义这些白血病的临床病理特征和最佳治疗策略的研究构成一个工作基础。
