Samoszuk M, Ramzi E
Pathology Department, University of California, Irvine 92717.
Leuk Lymphoma. 1993 Mar;9(4-5):315-9. doi: 10.3109/10428199309148528.
Tissues containing Hodgkin's disease tumors of the nodular sclerosis and mixed cellularity subtypes are frequently infiltrated by numerous degranulating eosinophils that release granule proteins such as eosinophil peroxidase and major basic protein. Until recently, the causes of the eosinophil infiltration and degranulation in Hodgkin's disease tumors were unknown. Analysis of Hodgkin's disease tissues by a sensitive and specific immunoperoxidase technique has now demonstrated the extensive presence of IgE in the Reed-Sternberg cells and adjacent cells of Hodgkin's disease tumors. Because eosinophils express a cell-surface receptor (CD23) for IgE and degranulate in the presence of IgE deposits, the extensive eosinophilia that is frequently present in Hodgkin's disease tumors is, at least in part, attributable to the IgE deposits within the tumor. In this review, we discuss the possible mechanisms and biological significance of IgE-related eosinophilia in Hodgkin's disease.
含有结节硬化型和混合细胞型霍奇金病肿瘤的组织经常被大量脱颗粒的嗜酸性粒细胞浸润，这些嗜酸性粒细胞会释放颗粒蛋白，如嗜酸性粒细胞过氧化物酶和主要碱性蛋白。直到最近，霍奇金病肿瘤中嗜酸性粒细胞浸润和脱颗粒的原因仍不清楚。现在，通过一种敏感且特异的免疫过氧化物酶技术对霍奇金病组织进行分析，结果显示在霍奇金病肿瘤的里德-斯腾伯格细胞及相邻细胞中广泛存在IgE。由于嗜酸性粒细胞表达IgE的细胞表面受体（CD23），并在有IgE沉积的情况下脱颗粒，因此霍奇金病肿瘤中经常出现的广泛嗜酸性粒细胞增多至少部分归因于肿瘤内的IgE沉积。在这篇综述中，我们讨论了霍奇金病中IgE相关嗜酸性粒细胞增多的可能机制和生物学意义。
