Fabricant R N, Todaro G J, Eldridge R
Lancet. 1979 Jan 6;1(8106):4-7. doi: 10.1016/s0140-6736(79)90452-5.
Nerve-growth factor (N.G.F.) from serum was assayed in 9 affected individuals from three kindreds with the trait "central neurofibromatosis". The hallmark of this disease is bilateral acoustic neuromas. Antigenic activity, as measured by radioimmunoassay, was significantly elevated. However, functional activity for N.G.F.; as measured by radioreceptor assay, was normal or low. This indicates that the central form of neurofibromatosis is characterised by high circulating N.G.F. levels which show low to normal function. These changes in N.G.F. differ from those in peripheral neurofibromatosis and suggest that the two hereditary conditions involve different alterations in N.G.F. synthesis and/or regulation.
对来自三个患有“中枢性神经纤维瘤病”家族的9名患者血清中的神经生长因子（N.G.F.）进行了检测。这种疾病的标志是双侧听神经瘤。通过放射免疫测定法测得的抗原活性显著升高。然而，通过放射受体测定法测得的N.G.F.功能活性正常或较低。这表明中枢性神经纤维瘤病的特征是循环中N.G.F.水平较高，但其功能显示为低至正常。N.G.F.的这些变化与外周性神经纤维瘤病不同，提示这两种遗传性疾病在N.G.F.合成和/或调节方面存在不同的改变。
